| #5 Aquilla is favored over #158 Burkeville by 45 | Matchup |
| #61 Balmorhea is favored over #156 Blackwell by 45 | Matchup |
| #55 Bluff Dale is favored over #129 Mount Calm by 45 | Matchup |
| #57 Cherokee is favored over #137 Rochelle by 45 | Matchup |
| #1 Gordon is favored over #42 Jonesboro by 45 | Matchup |
| #126 Guthrie is an underdog to #3 Jayton by 45 | Matchup |
| #4 Klondike is favored over #176 Amherst by 45 | Matchup |
| #31 Miami is favored over #33 Paducah by 6 | Matchup |
| #39 Milford is favored over #85 Saint Jo by 33 | Matchup |
| #9 Richland Springs is favored over #166 Calvert by 45 | Matchup |
| #174 Texas School for the Deaf is an underdog to #107 Carrollton Prince of Peace by 45 | Matchup |
| #74 Valley is an underdog to #53 Northside by 17 | Matchup |
| #2 Water Valley is favored over #14 Hermleigh by 39 | Matchup |
| #50 Zephyr is favored over #211 Evant by 45 | Matchup |
| #183 El Paso Leadership Academy is an underdog to #182 El Paso DaVinci by 1 | Matchup |
| #69 Fort Bend Homeschool is favored over #97 North Star by 18 | Matchup |
| #155 Greenville Christian is an underdog to #128 Amarillo San Jacinto by 18 | Matchup |
| #32 Houston Emery-Weiner is favored over #99 Corpus Christi Incarnate Word Academy by 45 | Matchup |
| #75 Irving Faustina is favored over #147 Waco Methodist Childrens Home by 45 | Matchup |
| #82 Lubbock Christ the King is favored over #112 Corpus Christi Annapolis by 19 | Matchup |
| #47 Marble Falls Faith is favored over #123 Wylie Preparatory by 45 | Matchup |
| #24 Rockwall Heritage is favored over #49 Abilene Christian by 24 | Matchup |
| #113 SA Saint Mary's Hall is an underdog to #96 Sugar Land Logos Prep by 9 | Matchup |
| #73 San Marcos Hill Country Christian is favored over #115 Midland Holy Cross by 23 | Matchup |
| #213 Waco Christian is favored over #220 Houston Texas Christian by 12 | Matchup |