probably not. Here's my reasoning:
With the season only being 10 games and so many teams, you don't get enough crossover between groups. These could be defined as geographical regions, or districts or even conferences. You certainly don't get enough to know a strength of schedule very quickly.
Honestly, the best indicator of your season is how you did last season. Of course players (and coaches) changes, but this is a lot more effective to start with. The key is to allow teams to have free range early in the season. What I mean by that is they much move a ton if things are off. Were two teams off, then do a huge course correction.
With six-man you also get some teams that are hugely different within their own season. What I mean by this are the teams that are great early, then maybe lose their top player or two and just aren't the same team. The result is they end up muddled somewhere in the middle of their good and bad. This can go the other way as well for teams that are 'late bloomers'
The system will always have errors in it. I now have over 260 teams in the preseason file and I think I am missing a few.